SIR2 calls upon the ER
نویسندگان
چکیده
منابع مشابه
The presence of an ER exit signal determines the protein sorting upon ER exit in yeast.
In yeast, there are at least two vesicle populations upon ER (endoplasmic reticulum) exit, one containing Gap1p (general aminoacid permease) and a glycosylated alpha-factor, gpalphaF (glycosylated proalpha-factor), and the other containing GPI (glycosylphosphatidylinositol)-anchored proteins, Gas1p (glycophospholipid-anchored surface protein) and Yps1p. We attempted to identify sorting determin...
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1 Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia 2 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia 3 Department of Pathology, The University of Melbourne, Parkville, VIC, Australia 4 Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia *Correspondence: ygal.haupt...
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Glycosylphosphatidylinositol (GPI)-anchored proteins exit the ER in distinct vesicles from other secretory proteins, and this sorting event requires the Rab GTPase Ypt1p, tethering factors Uso1p, and the conserved oligomeric Golgi complex. Here we show that proper sorting depended on the vSNAREs, Bos1p, Bet1p, and Sec22p. However, the t-SNARE Sed5p was not required for protein sorting upon ER e...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2005
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2005.10.006